Uptake of Monthly Intermittent Preventive Therapy with Sulphadoxin-Pyrimethamin Among Pregnant Women Attending a State Teaching Hospital in Ibadan

Abstract

Abstract

Objectives: This study assessed uptake of IPTp-SP among the pregnant women in a state hospital in Ibadan, and factors affecting the uptake.

Methods: It was a prospective cohort study of 223 pregnant women receiving care at the antenatal clinic of the facility between November 2018 to April 2019. Data was collected using a structured questionnaire and was analyzed using statistical package for social sciences (IBM SPSS, New York) version 21. P<0.05 was considered statistically significant. Chi-square tests was used for bivariate analysis and Ordinal logistic regression was used for multivariate analysis.

Result: The mean age of the participants was 29.91± 5.46 year with average booking gestational age of 23.26 ±3.99 weeks. Many of the participants took 4 doses (30.5%) while 45 (20.2%) participants had five doses. One hundred and eighty-eight (84.3%) received at least 3 doses of IPTp-SP. The commonest side effects were abdominal pain (OR=26.16, 95%CI =2.77-247.22) and dizziness(OR=5.43,95%CI=1.30-22.75) which were statistically significant on ordinal multivariate logistic regression with number of doses taken. A significant association was found between gestational age at booking (OR=0.64, 95%CI= 0.59-0.70) and number of doses of IPTp-SP taken on multivariate analysis.

Conclusion: Uptake of monthly IPTp-SP among pregnant women in Adeoyo hospital, Ibadan can be said to be good though associated with some minor side effects which significantly affected the uptake. Early booking was found to allow women to take the minimum of three doses of IPTp-SP recommended by WHO.

Keywords: malaria, pregnant, Ibadan, uptake, IPTp-SP