Acute Myeloid Leukaemia in Pregnancy: A Case Report

Abstract

Acute myeloid leukaemia (AML) during pregnancy is a rare and challenging condition that necessitates a delicate balance between maternal health and fetal well-being. This case report discusses a 32-year-old gravida 5 para 4 woman who presented at 12 weeks gestation with joint pains and was subsequently diagnosed with AML. Initial management was delayed due to cultural beliefs. Upon consent, she received the COAP regimen (Cyclophosphamide, Vincristine, Cytarabine, and Prednisolone) during the second trimester. Despite a satisfactory fetal outcome, the patient had sudden postpartum deterioration and maternal mortality. This case underscores the complexities of managing AML in pregnancy, emphasizing the importance of timely diagnosis, cultural sensitivity, and multidisciplinary care.

Keywords: Acute Myeloid Leukaemia, Pregnancy, Chemotherapy, Maternal Mortality, Fetal Outcome